Long-term remission in pediatric Wegener granulomatosis following allo-SCT after reduced-intensity conditioning
نویسندگان
چکیده
منابع مشابه
Long-term outcome of airway stenosis in granulomatosis with polyangiitis (Wegener granulomatosis): an observational study.
IMPORTANCE Airway stenosis occurs in patients with granulomatosis with polyangiitis (GPA or Wegener granulomatosis). It produces significant morbidity and contributes to mortality. OBJECTIVE To investigate the frequency and distribution of airway stenoses in GPA and evaluate the efficacy of local interventions in maintaining airway patency. DESIGN, SETTING, AND PARTICIPANTS A retrospective ...
متن کاملMaintaining remission in granulomatosis with polyangiitis ( Wegener ’ s )
Since the introduction of combined immunosuppressive therapy with oral cyclophosphamide (CYC) and glucocorticosteroids in the 1970s, the outcome of antineutrophil cytoplasmic antibody-associated vasculitides, for example, in granulomatosis with polyangiitis (Wegener`s), improved dramatically. However, the long-term follow-up of patients treated with CYC plus glucocorticosteroids has revealed hi...
متن کاملReduced-intensity conditioning allogeneic stem cell transplantation in pediatric patients.
PURPOSE/OBJECTIVES To determine if children undergoing reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation (RIC-AlloHSCT) have lower incidence of acute toxicities and, subsequently, require less supportive care than is required with myeloablative conditioning (MAC)-AlloHSCT. An additional purpose is to examine later outcomes by comparing 100-day transplantation-rel...
متن کاملAzacitidine after allo-SCT: the good without the bad?
In allo-SCT, the potential benefit of the GVL effect has always been offset by the detrimental effect of GVHD. For more than 4 decades, separation between GVHD and GVL remained challenging and has been considered the Holy Grail in the field of allo-SCT. Several direct and indirect lines of evidence already suggested a close correlation between GVHD and the risk of relapse after allo-SCT.2 Donor...
متن کاملEndonasal dacryocystorhinostomy in wegener granulomatosis.
Wegener granulomatosis (WG) is a life-threatening autoimmune disease of unknown etiology first described in 1936. The classic clinical triad consists of necrotizing granulomatous inflammation of the respiratory tract, necrotizing glomerulonephritis, and systemic vasculitis. Prior to the introduction of modern immunosuppressants, WG was usually fatal due to renal complications. Involvement of th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2010
ISSN: 0268-3369,1476-5365
DOI: 10.1038/bmt.2010.126